7th Global Nephrology Meeting
Cape Town, South Africa
Omega Mellyana
University/Dr. Kariadi Hospital, Indonesia
Title: The effects of combined vitamin C and E on the ox-LDL, sCD36, sVCAM-1, and NOx levels in idiopathic pediatric nephrotic syndrome
Biography
Biography: Omega Mellyana
Abstract
dy aimed to investigate whether combined supplementation of vitamin C and E were able to modify the ox-LDL, sCD36, sVCAM-1, and NOx levels in pediatric nephrotic syndrome patients. The study involved 36 children nephrotic syndrome patients allocated randomly into the treatment group and the placebo group (18 children each). The treatment group received combined supplementation of vitamin C and E. The serum levels of ox-LDL, sCD36, and sVCAM-1 were assayed by enzyme linked immunosorbent assay. The serum levels of NOx were assayed by colorimetric assay. The levels of ox-LDL, sVCAM-1, and NOx were decreased after treatment with combined supplementation of vitamin C and E, but can not reach statistically different (P>0.05) After treatment, there was an increase of sCD36 level in both groups both in treatment, although not significantly different (P>0.05). The level of ox-LDL was significantly lower in remission-INS group compared with non-remission-INS group (P < 0.05). The level of ox-LDL and sVCAM-1 were significantly lower in remission-treated group than that non remission-treated group (P < 0.05). In conclusion, combined supplementation of vitamin C and E cannot modify the ox-LDL, sCD36, sVCAM, and NOx levels in idiopathic pediatric nephrotic syndrome patients. In remission cases, combined supplementation of vitamin C and E reduces the ox-LDL and sVCAM-1 level.